Consumption of tetracyclines, sulphonamides and trimethoprim, and other antibacterials in the community, European Union/European Economic Area, 1997–2017

Abstract Objectives Data on consumption of tetracyclines, sulphonamides and trimethoprim, other antibacterials were collected from 30 EU/European Economic Area (EEA) countries over two decades. This article reviews temporal trends, seasonal variation, presence change-points changes in the composition main subgroups trimethoprim antibacterials. Methods For period 1997–2017, data tetracyclines (ATC group J01A), J01E), J01X) community aggregated at level active substance, using WHO ATC/DDD methodology (ATC/DDD index 2019). Consumption was expressed DDD per 1000 inhabitants day packages day. analysed based ATC-4 presented as compositional changes. Results In 2017, varied considerably between countries. Between 1997 did not change significantly, while its variation significantly decreased time. until 2006, The showed no significant time or variation. Conclusions wide variations EU/EEA represents an opportunity to further reduce these groups some improve quality their prescription.